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J Takeda Selected Research

Type 1 Maturity-Onset Diabetes of the Young

4/2003T130I mutation in HNF-4alpha gene is a loss-of-function mutation in hepatocytes and is associated with late-onset Type 2 diabetes mellitus in Japanese subjects.
1/2001Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects.
9/2000Identification of missense mutations in the hepatocyte nuclear factor-3beta gene in Japanese subjects with late-onset Type II diabetes mellitus.
1/2000Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3 beta and mutation screening in Japanese subjects with maturity-onset diabetes of the young.

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J Takeda Research Topics

Disease

10Neoplasms (Cancer)
05/2004 - 01/2000
6Stomach Neoplasms (Stomach Cancer)
01/2001 - 01/2000
5Mason-Type Diabetes
06/2014 - 01/2000
5Type 2 Diabetes Mellitus (MODY)
01/2002 - 01/2000
4Type 1 Maturity-Onset Diabetes of the Young
04/2003 - 01/2000
3Neoplasm Metastasis (Metastasis)
10/2001 - 01/2000
3Lymphatic Metastasis
01/2001 - 01/2000
2Ossification of the posterior longitudinal ligament of the spine
05/2001 - 01/2001
2Diabetes Mellitus
03/2001 - 01/2001
2Ischemia
02/2001 - 06/2000
2Carcinoma (Carcinomatosis)
01/2001 - 01/2000
2Cardiovascular Diseases (Cardiovascular Disease)
07/2000 - 06/2000
2Myocardial Ischemia (Ischemic Heart Diseases)
07/2000 - 06/2000
1Transient Myeloproliferative Syndrome
01/2018
1Uniparental Disomy
01/2017
1BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
01/2017
1Insulin Resistance
04/2015
1Glucose Intolerance
04/2015
1Fasciculation (Fasciculations)
01/2006
1Colitis
05/2004
1Cardiac Arrhythmias (Arrythmia)
12/2002
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
12/2002
1Myocardial Stunning (Stunned Myocardium)
12/2002
1Infarction (Infarctions)
12/2002
1Overweight
12/2002
1Body Weight (Weight, Body)
12/2002
1Pneumoperitoneum
11/2001
1Uterine Cervical Neoplasms (Cancer of the Cervix)
10/2001
1Adenocarcinoma
10/2001
1Anemia
05/2001
1Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria)
05/2001
1Hemolysis
05/2001
1Disease Progression
04/2001
1Inflammation (Inflammations)
04/2001
1Acidosis
02/2001
1Hypoxia (Hypoxemia)
02/2001
1Aortic Arch Aneurysm
11/2000
1Thoracic Aortic Aneurysm
11/2000
1Inguinal Hernia (Direct Inguinal Hernia)
10/2000
1Brain Death (Brain Dead)
09/2000
1Type 3 Maturity-Onset Diabetes of the Young
09/2000

Drug/Important Bio-Agent (IBA)

8Anesthetics (Anesthetic Agents)IBA
11/2000 - 02/2000
6Hepatocyte Nuclear FactorsIBA
04/2003 - 01/2000
4Proteins (Proteins, Gene)FDA Link
05/2001 - 01/2000
4Transcription Factors (Transcription Factor)IBA
03/2001 - 01/2000
3Fluorouracil (Carac)FDA LinkGeneric
01/2001 - 01/2000
2DNA (Deoxyribonucleic Acid)IBA
01/2017 - 08/2000
2beta CateninIBA
05/2004 - 10/2001
2Hepatocyte Nuclear Factor 1-alpha (Hepatocyte Nuclear Factor 1 alpha)IBA
12/2002 - 09/2000
2Biological ProductsIBA
03/2002 - 01/2001
2Biomarkers (Surrogate Marker)IBA
10/2001 - 04/2001
2Indicators and Reagents (Reagents)IBA
10/2001 - 01/2000
2Collagen Type XIIBA
05/2001 - 01/2001
2Insulin (Novolin)FDA Link
04/2001 - 01/2000
2beta-Galactosidase (Lactaid)IBA
08/2000 - 04/2000
1Tyrosine Kinase InhibitorsIBA
01/2017
1Tobacco Smoke Pollution (Passive Smoking)IBA
04/2015
1Glucose (Dextrose)FDA LinkGeneric
04/2015
1SmokeIBA
04/2015
1Hepatocyte Nuclear Factor 1IBA
06/2014
1PotassiumIBA
01/2006
1Vecuronium Bromide (Vecuronium)FDA LinkGeneric
01/2006
1Succinylcholine (Suxamethonium Chloride)FDA LinkGeneric
01/2006
1MagnesiumIBA
01/2006
1Dextrans (Dextran)FDA Link
05/2004
1SodiumIBA
05/2004
1Sevoflurane (Ultane)FDA LinkGeneric
12/2002
1Phosphotransferases (Kinase)IBA
03/2002
1CyclinsIBA
03/2002
1A-factor (Streptomyces)IBA
03/2002
1Hepatocyte Nuclear Factor 1-betaIBA
01/2002
1deoxyribonuclease II (DNASE II)IBA
05/2001
1Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)IBA
05/2001
1Complement System Proteins (Complement)IBA
05/2001
1PPAR gammaIBA
04/2001
1Forkhead Transcription Factors (Forkhead Box Proteins)IBA
03/2001
1Oxygen (Dioxygen)IBA
02/2001
1EndotoxinsIBA
02/2001
1Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
01/2001
1Orphan Nuclear ReceptorsIBA
01/2001
1Transforming Growth Factor alpha (TGF-alpha)IBA
01/2001
1ErbB Receptors (EGF Receptor)IBA
01/2001
1Epidermal Growth Factor (EGF)IBA
01/2001
1Cisplatin (Platino)FDA LinkGeneric
01/2001

Therapy/Procedure

4Therapeutics
01/2017 - 01/2000
4Gastrectomy
01/2001 - 01/2000
3Lymph Node Excision (Lymph Node Dissection)
01/2001 - 01/2000
2Drug Therapy (Chemotherapy)
01/2001 - 01/2000
2Stents
11/2000 - 02/2000
2General Anesthesia
05/2000 - 02/2000
1Transplantation
01/2018
1Colectomy
11/2001
1Hysterectomy
10/2001
1Epidural Anesthesia
02/2001
1Hepatectomy
01/2001
1Neoadjuvant Therapy
01/2001
1Thoracotomy
11/2000
1Ambulatory Surgical Procedures (Outpatient Surgery)
10/2000
1Decompression
09/2000
1Mechanical Ventilators (Ventilator)
09/2000